SIRT 1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor β1
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منابع مشابه
SIRT1 reduction causes renal and retinal injury in diabetes through endothelin 1 and transforming growth factor β1
In diabetes, hyperglycaemia causes up-regulation of endothelin 1 (ET-1) and transforming growth factor beta 1 (TGF-β1). Previously we showed glucose reduces sirtuin1 (SIRT1), a class III histone deacetylase. Here, we investigated the regulatory role of SIRT1 on ET-1 and TGF-β1 expression. Human microvascular endothelial cells were examined following incubation with 25 mmol/l glucose (HG) and 5 ...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2015
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.12557